Can CBD Cure Psychosis? New Research is Promising.

There’s new research surrounding cannabidiol (CBD) and its potential as a treatment for some of the most severe psychiatric conditions. Experts are calling it a promising sign. 

While tetrahydrocannabinol (THC), has long been associated with psychosis in some individuals, a new JAMA Psychiatry study suggests that CBD can have the opposite effect, “resetting” the psychosis-affected brain.

In the paper, a team of UK researchers show that a single dose of CBD can normalize brain activity associated with psychosis. Psychosis is associated with distinctive patterns of brain activation as detected by MRI in the striatum, medial temporal lobe, and midbrain. In a double-blind study of 33 people at high risk of psychosis and 19 healthy controls, the study’s authors found that patients at high risk of psychosis had abnormally elevated activity in these regions compared to the control subjects. But one large dose of CBD — 600 milligrams — quickly and significantly reduced the brain activity in those brain regions down to normal levels. “These results will clearly pave the way for developing a novel class of antipsychotic treatments,” Sagnik Bhattacharyya, M.D., Ph.D., a professor of translational neuroscience and psychiatry at King’s College London and the study’s first author, toldThe Guardian .

“We knew from previous studies that CBD had antipsychotic effects, but we didn’t know how it worked.” 

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